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KMID : 0364820110470010167
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Korean Journal of Microbiology
2011 Volume.47 No. 1 p.167 ~ p.169
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Temperature Sensitivity of Sigma Background Is Suppressed by the Disruption of ScKNS1 in Saccharomyces cerevisiae
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Park Yun-Hee
Park Hee-Moon
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Abstract
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The Saccharomyces cerevisiae S288c strain does not show haploid and diploid filamentous growth, and biofilm formation, because it has a flo8 nonsense mutation unlike Σ1278b strain which has a FLO8 gene. During the heat stress experiments to investigate the role of ScKns1, LAMMER kinase in S. cerevisiae, we found that Σ1278b strain revealed heat sensitivity at 37°C, a mild heat stress in contrast to S288c strain. We also found that the disruption of ScKns1 and the addition of sorbitol suppress heat sensitivity of Σ1278b strain. These results suggest the possibility that Flo8 and ScKns1 may interact to ransducer a signal for regulating heat stress through a novel signaling pathway.
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KEYWORD
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FLO8, Saccharomyces cerevisiae, ScKNS1, Σ1278b, temperature sensitivity
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